The Bed Nucleus of the Stria Terminalis: Translational Deep Brain Stimulation to Reduce Anxiety
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چکیده
منابع مشابه
Can electrical stimulation of the human bed nucleus of the stria terminalis reduce contextual anxiety? An unanswered question
Citation: Luyck K and Luyten L (2015) Can electrical stimulation of the human bed nucleus of the stria terminalis reduce contextual anxiety? An unanswered question. In their paper, Baas et al. (2014), take the rather unique opportunity to conduct a human fear conditioning experiment in subjects with stimulation electrodes in the nucleus accumbens and internal capsule. Here, we argue that it mig...
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s | 3 reinstatement was accompanied by reduction of synaptic input in the IL. Then we hypothesized that prefrontal dopamine plays a key role in reinstatement and tested this idea. A reminder shock induced c-Fos expression in the IL-projecting dopaminergic neurons in the ventral tegmental area. Blocking of IL dopamine D1 receptor signaling prevented reduction of synaptic input, CeM c-Fos express...
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In children, behavioral inhibition (BI) in response to potential threat predicts the development of anxiety and affective disorders, and primate lesion studies suggest involvement of the orbitofrontal cortex (OFC) in mediating BI. Lesion studies are essential for establishing causality in brain-behavior relationships, but should be interpreted cautiously because the impact of a discrete lesion ...
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The bed nucleus of the stria terminalis (BST) in the rat forebrain differs between males and females. To test whether apoptosis may contribute to the development of sex differences in the BST, the incidence of apoptosis was determined in sham-treated males and sham-treated females sacrificed on postnatal days (PN) 2, 4, 6, 8, 10, and 12 (PN 1 being day of birth). More apoptotic nuclei were foun...
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ژورنال
عنوان ژورنال: The Neuroscientist
سال: 2020
ISSN: 1073-8584,1089-4098
DOI: 10.1177/1073858419898381